About rune
I think the most famous ones are vio and vamp, but I recommend desp and rev.
If you use vio, I recommend him with turn1 team
If you use vamp, I recommend him with turn2 team
desp and his passive are very good together
For example, if there is an enemy monster who has no will set, you can get a big advantage if you can stun it first.
Especially against cc team, if you can do it, the enemy may surrender.
Vamp can work well later in the game, but I think desp is more advantageous.
About artifact
I recommend hp as the main option.
For the left sub-option, I recommend DMG taken from fire.
For the sub option on the right, I recommend increasing the crdmg of skill1 and skill2.
DMG taken from fire is necessary because you are often targeted by kassandra, verde, masha, etc.
about the priority status
Prioritize statuses in order of res, hp, def, cri rate, crdmg, atk, acc
About hp
I think you should aim for +25k in the end.
(It depends on the rank range you are aiming for, but +20k or more is necessary.
Especially, you need more hp to avoid being defeated by kassandra's attack.
About def
There is no specific value to aim for, but +700 or more is necessary.
about atk
Aim for +500 or so, although this is not a priority.
about speed
Not necessary.
About res
max is recommended
About acc
Low priority, but 10% is necessary
usage
If the enemy uses cc team, miles, beast rider, chimera, etc., always pick him.
Basically, my team's monsters are slow, so I always pick him against enemies who are likely to have a big speed difference.
I often use it with riley
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